Changes in blood pressure and heart rate by ketamine with and without succinylcholine

Authors

  • Andrés Callegari M Ex Profesor Principal, Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú
  • Pedro P. Álvarez-Falconí Ex Tutor de Anestesiología, Escuela de Graduados, Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú Instituto Nacional de Salud; Lima, Perú.
  • Edmundo Céspedes Ex Médico Anestesiólogo de la Clínica Maison de Santé; Lima, Perú.

DOI:

https://doi.org/10.15381/anales.v72i2.994

Keywords:

Ketamine, succinylcholine, anesthesia, blood pressure, heart rate.

Abstract

Abstract Introduction: Ketamine is used as a general anesthetic as well as for anesthesia induction and analgesia. Objectives: To assess modifications in systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) caused by ketamine, and if there is any influence of succinylcholine. Design: Comparative and observational study. Setting: Maison de Santé Clinic, Lima, Peru. Participants: Patients receiving ketamine. Interventions: Ketamine was used as a single drug for general anesthesia and for induction. Twelve patients were considered for each modality. The twelve first patients received ketamine, 2 mg/kg IV, and SBP, DBP and HR were measured before and after administering the drug. The second group received ketamine plus succinylcholine, and same parameters were measured. Main outcome measures: SBP, DBP, and HR variations. Results: Following ketamine injection in the first twelve patients there were elevations in SBP 26 ± 3 mmHg, p < 0,001, DBP 19 ± 3 mmHg, p < 0,001, and HR 15 ± 3 per minute, p < 0,001. In the second group after ketamine plus succinylcholine administration there were increases in SBP 28 ± 3 mmHg, p < 0,001, DBP 18 ± 2 mmHg, p < 0,001, and HR 13 ± 1 per minute, p < 0,001. There were no statistically significant differences when comparing both groups, i.e. succinlycholine did not have any influence in modifying the aforementioned parameters. Conclusions: Increases in blood pressure and heart rate induced by ketamine were not affected by succinylcholine.

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Published

2011-06-13

Issue

Vol. 72 No. 2 (2011)

Section

Trabajos originales

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Copyright (c) 2011 Andrés Callegari M, Pedro P. Álvarez-Falconí, Edmundo Céspedes

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How to Cite

1.
Callegari M A, Álvarez-Falconí PP, Céspedes E. Changes in blood pressure and heart rate by ketamine with and without succinylcholine. An Fac med [Internet]. 2011 Jun. 13 [cited 2024 Jul. 3];72(2):131-5. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/994