Actividad antimicótica in vitro y elucidación estructural del aceite esencial de las hojas de Minthostachys mollis "Muña"

Authors

  • Carlos Cano Pérez Instituto de Ciencias Farmacéuticas y Recursos Naturales "Juan de Dios Guevara" Facultad de Farmacia y Bioquímica de la Universidad Nacional Mayor de San Marcos, Lima, Perú.
  • Pablo Bonilla Rivera Instituto de Ciencias Farmacéuticas y Recursos Naturales "Juan de Dios Guevara" Facultad de Farmacia y Bioquímica de la Universidad Nacional Mayor de San Marcos, Lima, Perú.
  • Mirtha Roque A. Instituto en Química Biológica, Microbiología y Biotecnología "Marco Antonio Garrido Malo" Facultad de Farmacia y Bioquímica de la Universidad Nacional Mayor de San Marcos, Lima, Perú.
  • Julio Ruiz Quiroz Instituto en Química Biológica, Microbiología y Biotecnología "Marco Antonio Garrido Malo" Facultad de Farmacia y Bioquímica de la Universidad Nacional Mayor de San Marcos, Lima, Perú.

DOI:

https://doi.org/10.15381/ci.v9i1.5075

Keywords:

Minthostachys mollis, essential oil, antimycotic activity, gas chromatography, monoterpenes

Abstract

The objective of this paper is ta demonstrate the in vitro antimycotic activity and elucidation of sorne metabolites of the essentiaI oil of Minthostachys mollis (muña) that comes from the district of Huacrapuquio (2700m. altitude) in the province of Tarma. The essential oil of the leaves of Minthostachys mollis (muña) has been extracted by hydrodistillation method. This was subjected to Physical-Chemical analysis, Gas Chromatography (CC) to determine the chemical compasitian and then determining that fungicidal and fungistatic activity to be due to the following Monoterpenes: Pulegone, Limoneno, Menthone and also Myrcene. The antimycotic activity for Candida albicans was determined by the Agar-well diffusion assay and the method of dilution in tubes, the inhibition of growth of Trichophytun tonsurans, Trichophytun mentagophytus, Microsporun canis. For the diffusion in Agar test the diameters were as follows 30 mm for the 100% concentration of the essential muña oil and 35 mm for the 50% concentration of the same oil. The essential oil of muña inhibited growth of Trichophytun tonsurans, Trichophytun mentagophtus, Microsporun canis, probably by monoterpenes pharmacological action.

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Published

2006-06-19

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Section

Artículos Originales

How to Cite

1.
Cano Pérez C, Bonilla Rivera P, Roque A. M, Ruiz Quiroz J. Actividad antimicótica in vitro y elucidación estructural del aceite esencial de las hojas de Minthostachys mollis "Muña". Ciencia e investigación [Internet]. 2006 Jun. 19 [cited 2024 Aug. 16];9(1):27-31. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/farma/article/view/5075