Antitumoral effect of the aqueous extracts of Bomarea cornigera (Alstroe- meriaceae) on the sarcoma induced in mice

Authors

  • Christian Villanueva 1 Laboratorio de Reproducción y Biología de Desarrollo. Facultad de Ciencias Biológicas. Univer- sidad Nacional Mayor de San Marcos, Ciudad Universitaria, Av. Venezuela s/n. Apartado postal 11-058, Lima 11. 2 Asociación Presservaris. Calle Felix Tello Mz K lot 2 Urb. Honor y Lealtad, Surco. Lima, Perú. Teléfo- no. 51 1 2577556.
  • Claudia Rodríguez 1 Laboratorio de Reproducción y Biología de Desarrollo. Facultad de Ciencias Biológicas. Univer- sidad Nacional Mayor de San Marcos, Ciudad Universitaria, Av. Venezuela s/n. Apartado postal 11-058, Lima 11. 2 Asociación Presservaris. Calle Felix Tello Mz K lot 2 Urb. Honor y Lealtad, Surco. Lima, Perú. Teléfo- no. 51 1 2577556.
  • Karol Lavado 1 Laboratorio de Reproducción y Biología de Desarrollo. Facultad de Ciencias Biológicas. Univer- sidad Nacional Mayor de San Marcos, Ciudad Universitaria, Av. Venezuela s/n. Apartado postal 11-058, Lima 11.
  • Melissa Barbieri Asociación Presservaris. Calle Felix Tello Mz K lot 2 Urb. Honor y Lealtad, Surco. Lima, Perú. Teléfo- no. 51 1 2577556.
  • Luis Guzmán 1 Laboratorio de Reproducción y Biología de Desarrollo. Facultad de Ciencias Biológicas. Univer- sidad Nacional Mayor de San Marcos, Ciudad Universitaria, Av. Venezuela s/n. Apartado postal 11-058, Lima 11. 2 Asociación Presservaris. Calle Felix Tello Mz K lot 2 Urb. Honor y Lealtad, Surco. Lima, Perú. Teléfo- no. 51 1 2577556.
  • Ricardo Alfaro 1 Laboratorio de Reproducción y Biología de Desarrollo. Facultad de Ciencias Biológicas. Univer- sidad Nacional Mayor de San Marcos, Ciudad Universitaria, Av. Venezuela s/n. Apartado postal 11-058, Lima 11. 2 Asociación Presservaris. Calle Felix Tello Mz K lot 2 Urb. Honor y Lealtad, Surco. Lima, Perú. Teléfo- no. 51 1 2577556.
  • José Pino 1 Laboratorio de Reproducción y Biología de Desarrollo. Facultad de Ciencias Biológicas. Univer- sidad Nacional Mayor de San Marcos, Ciudad Universitaria, Av. Venezuela s/n. Apartado postal 11-058, Lima 11.

DOI:

https://doi.org/10.15381/rpb.v17i3.16

Keywords:

Bomarea cornigera, antitumor, medicinal plant TG-180, cancer.

Abstract

We investigated antitumor effect of aqueous extract of Bomarea cornigera. Swiss albino mice strain were inoculated with tumor cell line TG-180 for 15 days, after which they were separated into 5 groups (n= 5 per group). Cyclophosphamide was administered intraperitoneally (positive control), distilled water (negative control) and the aqueous extract at concentrations of 1X, 2X and 4X; the morbidity, mortality, weight and length of the sarcoma were assessed. We found an inhibitory effect of extract of B. cornigera in the development of solid tumor in mice where the TG-180 sarcoma was transplanted. The inhibition rates were 87.44 and 8.52% after 17 days of treatment, considering 1X dose (lowest) and 2X (intermediate), respectively. These results suggest that administration of aqueous extract of B. cornigera intraperitoneally may be useful as a cancer inhibitor.

Downloads

Download data is not yet available.

Downloads

Published

12/31/2010

Issue

Vol. 17 No. 3 (2010)

Section

Notes

License

Copyright (c) 2010 Christian Villanueva, Claudia Rodríguez, Karol Lavado, Melissa Barbieri, Luis Guzmán, Ricardo Alfaro, José Pino

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

AUTHORS RETAIN THEIR RIGHTS:

a. Authors retain their trade mark rights and patent, and also on any process or procedure described in the article.

b. Authors retain their right to share, copy, distribute, perform and publicly communicate their article (eg, to place their article in an institutional repository or publish it in a book), with an acknowledgment of its initial publication in the Revista Peruana de Biologia.

c. Authors retain theirs right to make a subsequent publication of their work, to use the article or any part thereof (eg a compilation of his papers, lecture notes, thesis, or a book), always indicating its initial publication in the Revista Peruana de Biologia (the originator of the work, journal, volume, number and date).

How to Cite

Villanueva, Christian, Claudia Rodríguez, Karol Lavado, Melissa Barbieri, Luis Guzmán, Ricardo Alfaro, and José Pino. 2010. “Antitumoral Effect of the Aqueous Extracts of Bomarea Cornigera (Alstroe- Meriaceae) on the Sarcoma Induced in Mice”. Revista Peruana De Biología 17 (3): 385-88. https://doi.org/10.15381/rpb.v17i3.16.