Association of Clostridium difficile, its toxin A and histopathological damage in patients with nosocomial diarrhea

Authors

  • Enrique Martin-Alva Departamento de Microbiología y Parasitología, Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, Ciudad Universitaria, Av Juan Pablo II S/N. Trujillo, Perú.
  • Flora Chávez Departamento de Microbiología y Parasitología, Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, Ciudad Universitaria, Av Juan Pablo II S/N. Trujillo, Perú.
  • Pedro Mercado Departamento de Microbiología y Parasitología, Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, Ciudad Universitaria, Av Juan Pablo II S/N. Trujillo, Perú.

DOI:

https://doi.org/10.15381/rpb.v14i2.1808

Keywords:

Antibiotic associated diarrhoea, Clotridium difficile, histopathological damage, toxin A, pseudomembranous cholitis

Abstract

This study determines the association of Clotridium difficile and its toxin A with the histopathological damage in patients from the Gastroenterology Service of Victor Lazarte Echegaray Hospital, Trujillo-Perú from january to august, 2003. The study was done in 24 patients admitted with treatment of nosocomial diarrhea. Stool samples were colleted from each patient to diagnose C. difficile and its toxin A using a commercial kit (Oxoid). The evaluation histological of damage was made in each patients, the damage were typified in three types of lesions (I, II or III). It was found that 18 (75%) patients had C. difficile, but only 15 (62,5%) of them had toxin A in faeces and three (12,5%) did not have colonic lesion. The lesion type I, was the most predominant (37,5%). From nine patients without toxin A in faeces, one (4,16%) had C. diffficile and colonic lesion, by the other hand, two (8,33%) patients did not have toxin A and C. difficile but they had colonic lesion type I. It was not association between C. difficile and its toxin A. There is an important increase of C. difficile incidence. The presence of patients with C. difficile but without toxin A is explained by the existence of atoxigenic strains, being the lesions produce by several causes, not only by the presence of toxins.

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Published

12/31/2007

Issue

Vol. 14 No. 2 (2007)

Section

Articles

License

Copyright (c) 2007 Enrique Martin-Alva, Flora Chávez, Pedro Mercado

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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c. Authors retain theirs right to make a subsequent publication of their work, to use the article or any part thereof (eg a compilation of his papers, lecture notes, thesis, or a book), always indicating its initial publication in the Revista Peruana de Biologia (the originator of the work, journal, volume, number and date).

How to Cite

Martin-Alva, Enrique, Flora Chávez, and Pedro Mercado. 2007. “Association of Clostridium Difficile, Its Toxin A and Histopathological Damage in Patients With Nosocomial Diarrhea”. Revista Peruana De Biología 14 (2): 287-90. https://doi.org/10.15381/rpb.v14i2.1808.