In vitro antifungal activity of crude extracts of Piper tuberculatum

Authors

  • Zahyda G.F. Palacios Facultad de Ciencias Biológicas, Universidad Nacional Pedro Ruiz Gallo, Ciudad Universitaria, Juan XXIII No 391, Lambayeque, Perú.
  • Guillermo E. Delgado Facultad de Ciencias Biológicas, Universidad Nacional Pedro Ruiz Gallo, Ciudad Universitaria, Juan XXIII No 391, Lambayeque, Perú.
  • Mario C. Moreno Facultad de Ciencias Biológicas, Universidad Nacional Pedro Ruiz Gallo, Ciudad Universitaria, Juan XXIII No 391, Lambayeque, Perú.
  • Massuo J. Kato Instituto de Química, Universidade de São Paulo, C.P. 26077, 05513-970, São Paulo, Brasil.
  • Consuelo Rojas Facultad de Ciencias Biológicas, Universidad Nacional Pedro Ruiz Gallo, Ciudad Universitaria, Juan XXIII No 391, Lambayeque, Perú.

DOI:

https://doi.org/10.15381/rpb.v16i2.208

Keywords:

CH2Cl2, MeOH extract, Microsporum canis, M. gypseum, tissue culture, Trichophyton rubrum.

Abstract

Piper tuberculatum Jacq. (Piperaceae) is used in traditional Peruvian medicine as anti-inflammatory and disinfectant of wounds in humans and domestic animals. This species contains amides bearing isobutyl, pyrrolidine, dihydropyridone and piperidine moieties. The aim of this work was to investigate antifungal activity of crude extracts from the spikes, leaves and stems of wild plants extracted with CH2Cl2:MeOH (2:1), EtOH, decoction, and in vitro plants extracted with CH2Cl2:MeOH (2:1). The crude extracts showed antifungal activity on Trichophyton rubrum, Mycosporum canis y M. gypseum. The minimum inhibitory concentration (MIC) observed with CH2Cl2:MeOH (2:1), EtOH and decoctions extracts against T. rubrum, M. canis and M. gypseum was 0,1 mg/mL for spikes and leaves, and 0,1 to 0,5 mg/mL for stems. The inhibition of growth using in vitro plants on T. rubrum and M. canis was 100% in 0,5 mg/mL, and 95% on M. gypseum 95% using 1,5 mg/mL of concentration.

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Published

12/31/2009

Issue

Vol. 16 No. 2 (2009)

Section

Articles

License

Copyright (c) 2009 Zahyda G.F. Palacios, Guillermo E. Delgado, Mario C. Moreno, Massuo J. Kato, Consuelo Rojas

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

AUTHORS RETAIN THEIR RIGHTS:

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b. Authors retain their right to share, copy, distribute, perform and publicly communicate their article (eg, to place their article in an institutional repository or publish it in a book), with an acknowledgment of its initial publication in the Revista Peruana de Biologia.

c. Authors retain theirs right to make a subsequent publication of their work, to use the article or any part thereof (eg a compilation of his papers, lecture notes, thesis, or a book), always indicating its initial publication in the Revista Peruana de Biologia (the originator of the work, journal, volume, number and date).

How to Cite

Palacios, Zahyda G.F., Guillermo E. Delgado, Mario C. Moreno, Massuo J. Kato, and Consuelo Rojas. 2009. “In Vitro Antifungal Activity of Crude Extracts of Piper Tuberculatum”. Revista Peruana De Biología 16 (2): 209-14. https://doi.org/10.15381/rpb.v16i2.208.