Embryotoxic and teratogenic effect of Ruta chalepensis L. «rue», in mouse (Mus musculus)

Authors

  • José Gonzales Universidad Nacional Mayor de San Marcos, Facultad de Ciencias Biológicas, Instituto de Investigación de Ciencias Biológicas Antonio Raimondi; José Gonzales: Laboratorio de Reproducción y Biología del Desarrollo. Facultad de Ciencias Biológicas. Universidad Nacional Mayor de San Marcos
  • Victor Benavides Universidad Nacional Mayor de San Marcos, Facultad de Ciencias Biológicas, Instituto de Investigación de Ciencias Biológicas Antonio Raimondi; José Gonzales: Laboratorio de Reproducción y Biología del Desarrollo. Facultad de Ciencias Biológicas. Universidad Nacional Mayor de San Marcos
  • Ruth Rojas Universidad Nacional Mayor de San Marcos, Facultad de Ciencias Biológicas, Instituto de Investigación de Ciencias Biológicas Antonio Raimondi; José Gonzales: Laboratorio de Reproducción y Biología del Desarrollo. Facultad de Ciencias Biológicas. Universidad Nacional Mayor de San Marcos
  • José Pino Universidad Nacional Mayor de San Marcos, Facultad de Ciencias Biológicas, Instituto de Investigación de Ciencias Biológicas Antonio Raimondi; José Gonzales: Laboratorio de Reproducción y Biología del Desarrollo. Facultad de Ciencias Biológicas. Universidad Nacional Mayor de San Marcos

DOI:

https://doi.org/10.15381/rpb.v13i3.2344

Keywords:

Ruta chalepensis, embriotoxicity, teratogenicity, mouse, postimplantational

Abstract

Ruta graveolens L. and R. chalepensis L. are plants used in folkloric medicine as antispasmodics, antihelmintics, antimicrobials, emmenagoges and abortifacients. In this work we evaluated embryotoxic effect of liophilized aqueous extract (LAE) of leaves of R. chalepensis on postimplantational mouse embryos. Pregnant albino mice received intraperitoneally (ip) 10 mg of liophilzed rue/kg of body weight (treated group, n=12) during post implantational period (day 9 - day 17 postcopula), and a control (C) group, n=18, received only distilled water during the same period of time. The LAE of R. chalepensis did not affect negatively the weight of mother but affected the weight of the uterus during the period of treatment (p<0,05). The frequency of fetal resorptions was greater (p<0,05) and a significant decrease of fetal weight (p<0,01) was evidenced in fetuses of the treated group in comparison with the C group. Also there was occurrence of skeletal malformations in the treated group. In conclusion, we found that LAE of R. chalepensis shows embryotoxic effects on mouse esposed during postimplantational period.

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Published

12/29/2006

Issue

Vol. 13 No. 3 (2006)

Section

Articles

License

Copyright (c) 2006 José Gonzales, Victor Benavides, Ruth Rojas, José Pino

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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b. Authors retain their right to share, copy, distribute, perform and publicly communicate their article (eg, to place their article in an institutional repository or publish it in a book), with an acknowledgment of its initial publication in the Revista Peruana de Biologia.

c. Authors retain theirs right to make a subsequent publication of their work, to use the article or any part thereof (eg a compilation of his papers, lecture notes, thesis, or a book), always indicating its initial publication in the Revista Peruana de Biologia (the originator of the work, journal, volume, number and date).

How to Cite

Gonzales, José, Victor Benavides, Ruth Rojas, and José Pino. 2006. “Embryotoxic and Teratogenic Effect of Ruta Chalepensis L. «rue», in Mouse (Mus Musculus)”. Revista Peruana De Biología 13 (3): 223-25. https://doi.org/10.15381/rpb.v13i3.2344.